| 06.11.2021 11:00 | FC Mecklenburg Schwerin | - | 1. FC Lokomotive Leipzig | 0 | : | 2 |
| 06.11.2021 11:00 | Tennis Borussia Berlin | - | 1. FC Union Berlin II | 3 | : | 2 |
| 06.11.2021 12:00 | FSV Bernau | - | RasenBallsport Leipzig II | 1 | : | 3 |
| 06.11.2021 12:00 | 1. FC Magdeburg | - | FC Carl Zeiss Jena II | 4 | : | 0 |
| 07.11.2021 11:00 | FC Rot-Weiß Erfurt | - | SC Borea Dresden | 1 | : | 5 |
| 07.11.2021 12:00 | SG Dynamo Dresden II | - | SSV 07 Schlotheim | 4 | : | 0 |
| 07.11.2021 12:00 | SV Babelsberg 03 | - | Hertha BSC II | 0 | : | 0 |
| 07.11.2021 12:00 | 1. FC Neubrandenburg 04 | - | Hallescher FC II | 1 | : | 1 |
| 07.11.2021 14:00 | Füchse Berlin | - | SV Dessau 05 | 3 | : | 0 |
Spielfrei: SV Empor Berlin
| Sp. | Pkt. | Tore | Diff. | |||
|---|---|---|---|---|---|---|
| 1 | 1. FC Magdeburg | 9 | 25 | 31:2 | 29 | |
| 2 | RasenBallsport Leipzig II | 9 | 24 | 25:9 | 16 | |
| 3 | Hertha BSC II | 9 | 20 | 27:4 | 23 | |
| 4 | Tennis Borussia Berlin | 9 | 17 | 17:10 | 7 | |
| 5 | Füchse Berlin | 9 | 16 | 13:7 | 6 | |
| 6 | SG Dynamo Dresden II | 10 | 16 | 17:17 | 0 | |
| 7 | SC Borea Dresden | 10 | 15 | 17:14 | 3 | |
| 8 | 1. FC Union Berlin II | 10 | 14 | 19:17 | 2 | |
| 9 | SV Empor Berlin | 9 | 12 | 11:12 | -1 | |
| 10 | 1. FC Lokomotive Leipzig | 10 | 12 | 16:18 | -2 | |
| 11 | FSV Bernau | 10 | 11 | 26:25 | 1 | |
| 12 | FC Mecklenburg Schwerin | 9 | 11 | 13:21 | -8 | |
| 13 | 1. FC Neubrandenburg 04 | 10 | 11 | 10:23 | -13 | |
| 14 | SV Babelsberg 03 | 10 | 10 | 9:12 | -3 | |
| 15 | SSV 07 Schlotheim | 9 | 10 | 10:21 | -11 | |
| 16 | FC Carl Zeiss Jena II | 10 | 9 | 14:24 | -10 | |
| 17 | Hallescher FC II | 9 | 8 | 13:17 | -4 | |
| 18 | FC Rot-Weiß Erfurt | 9 | 6 | 14:25 | -11 | |
| 19 | SV Dessau 05 | 10 | 1 | 3:27 | -24 |
Hinweis: Tabellenstand ohne vorgezogene Spiele!
| 12.11.2021 18:30 | SV Dessau 05 | - | 1. FC Magdeburg | 0 | : | 2 |
| 13.11.2021 12:00 | Hallescher FC II | - | SV Babelsberg 03 | 1 | : | 2 |
| 13.11.2021 13:00 | FC Carl Zeiss Jena II | - | Tennis Borussia Berlin | 0 | : | 4 |
| 13.11.2021 13:00 | Hertha BSC II | - | FSV Bernau | 4 | : | 1 |
| 14.11.2021 12:00 | 1. FC Union Berlin II | - | FC Mecklenburg Schwerin | 6 | : | 2 |
| 14.11.2021 12:00 | SSV 07 Schlotheim | - | Füchse Berlin | 2 | : | 2 |
| 14.11.2021 12:00 | RasenBallsport Leipzig II | - | SG Dynamo Dresden II | 2 | : | 1 |
| 21.11.2021 14:00 | SV Empor Berlin | - | 1. FC Neubrandenburg 04 | 3 | : | 0 |
| 20.02.2022 12:00 | 1. FC Lokomotive Leipzig | - | FC Rot-Weiß Erfurt | 0 | : | 0 |
Spielfrei: SC Borea Dresden