| 23.10.2021 10:00 | FC Mecklenburg Schwerin | - | FC Rot-Weiß Erfurt | 5 | : | 3 |
| 23.10.2021 11:00 | 1. FC Neubrandenburg 04 | - | RasenBallsport Leipzig II | 0 | : | 3 |
| 23.10.2021 12:00 | Tennis Borussia Berlin | - | SC Borea Dresden | 3 | : | 0 |
| 23.10.2021 12:00 | FSV Bernau | - | SV Dessau 05 | 3 | : | 0 |
| 23.10.2021 15:30 | 1. FC Magdeburg | - | 1. FC Lokomotive Leipzig | 3 | : | 0 |
| 24.10.2021 12:00 | SV Babelsberg 03 | - | SSV 07 Schlotheim | 1 | : | 2 |
| 24.10.2021 12:00 | SV Empor Berlin | - | Hertha BSC II | 1 | : | 0 |
| 24.10.2021 12:00 | SG Dynamo Dresden II | - | FC Carl Zeiss Jena II | 4 | : | 2 |
| 24.11.2021 18:30 | Füchse Berlin | - | 1. FC Union Berlin II | 3 | : | 3 |
Spielfrei: Hallescher FC II
| Sp. | Pkt. | Tore | Diff. | |||
|---|---|---|---|---|---|---|
| 1 | 1. FC Magdeburg | 7 | 19 | 23:2 | 21 | |
| 2 | RasenBallsport Leipzig II | 7 | 18 | 20:7 | 13 | |
| 3 | Hertha BSC II | 7 | 16 | 20:4 | 16 | |
| 4 | 1. FC Union Berlin II | 8 | 14 | 17:10 | 7 | |
| 5 | FSV Bernau | 8 | 11 | 25:19 | 6 | |
| 6 | Tennis Borussia Berlin | 7 | 11 | 13:8 | 5 | |
| 7 | SV Empor Berlin | 8 | 11 | 11:12 | -1 | |
| 8 | SC Borea Dresden | 8 | 11 | 10:11 | -1 | |
| 9 | Füchse Berlin | 7 | 10 | 8:7 | 1 | |
| 10 | FC Mecklenburg Schwerin | 7 | 10 | 11:17 | -6 | |
| 11 | SG Dynamo Dresden II | 8 | 10 | 11:17 | -6 | |
| 12 | 1. FC Neubrandenburg 04 | 8 | 10 | 9:15 | -6 | |
| 13 | SV Babelsberg 03 | 8 | 9 | 8:10 | -2 | |
| 14 | 1. FC Lokomotive Leipzig | 8 | 9 | 14:17 | -3 | |
| 15 | FC Carl Zeiss Jena II | 8 | 9 | 14:18 | -4 | |
| 16 | SSV 07 Schlotheim | 7 | 7 | 7:17 | -10 | |
| 17 | Hallescher FC II | 7 | 6 | 12:16 | -4 | |
| 18 | FC Rot-Weiß Erfurt | 8 | 6 | 13:20 | -7 | |
| 19 | SV Dessau 05 | 8 | 1 | 3:22 | -19 |
Hinweis: Tabellenstand ohne vorgezogene Spiele!
| 10.10.2021 13:00 | RasenBallsport Leipzig II | - | SV Babelsberg 03 | 2 | : | 1 |
| 30.10.2021 12:00 | FC Carl Zeiss Jena II | - | Füchse Berlin | 0 | : | 2 |
| 30.10.2021 12:00 | SC Borea Dresden | - | FC Mecklenburg Schwerin | 2 | : | 2 |
| 30.10.2021 12:00 | Hertha BSC II | - | 1. FC Neubrandenburg 04 | 7 | : | 0 |
| 31.10.2021 12:00 | 1. FC Lokomotive Leipzig | - | Tennis Borussia Berlin | 0 | : | 1 |
| 31.10.2021 12:00 | SSV 07 Schlotheim | - | FSV Bernau | 3 | : | 0 |
| 31.10.2021 12:00 | Hallescher FC II | - | SV Empor Berlin | 0 | : | 0 |
| 31.10.2021 12:00 | SV Dessau 05 | - | SG Dynamo Dresden II | 0 | : | 2 |
| 31.10.2021 13:00 | 1. FC Union Berlin II | - | 1. FC Magdeburg | 0 | : | 4 |
Spielfrei: FC Rot-Weiß Erfurt