| 03.09.2021 18:30 | RasenBallsport Leipzig II | - | SV Dessau 05 | 5 | : | 0 |
| 04.09.2021 12:00 | SV Empor Berlin | - | 1. FC Lokomotive Leipzig | 1 | : | 3 |
| 04.09.2021 13:00 | Hertha BSC II | - | FC Carl Zeiss Jena II | 2 | : | 1 |
| 05.09.2021 11:00 | 1. FC Neubrandenburg 04 | - | SC Borea Dresden | 1 | : | 0 |
| 05.09.2021 12:00 | SG Dynamo Dresden II | - | Tennis Borussia Berlin | 1 | : | 1 |
| 05.09.2021 12:00 | FSV Bernau | - | FC Mecklenburg Schwerin | 3 | : | 0 |
| 05.09.2021 12:00 | SV Babelsberg 03 | - | FC Rot-Weiß Erfurt | 2 | : | 1 |
| 20.11.2021 13:00 | Füchse Berlin | - | 1. FC Magdeburg | 0 | : | 0 |
| 27.02.2022 13:00 | Hallescher FC II | - | 1. FC Union Berlin II | 0 | : | 3 |
Spielfrei: SSV 07 Schlotheim
| Sp. | Pkt. | Tore | Diff. | |||
|---|---|---|---|---|---|---|
| 1 | RasenBallsport Leipzig II | 2 | 6 | 9:1 | 8 | |
| 2 | 1. FC Magdeburg | 2 | 4 | 8:0 | 8 | |
| 3 | FSV Bernau | 2 | 4 | 6:3 | 3 | |
| 4 | 1. FC Union Berlin II | 2 | 4 | 5:2 | 3 | |
| 5 | Hertha BSC II | 2 | 4 | 4:3 | 1 | |
| 6 | SV Babelsberg 03 | 2 | 4 | 3:2 | 1 | |
| 7 | Hallescher FC II | 2 | 3 | 4:4 | 0 | |
| 8 | FC Rot-Weiß Erfurt | 2 | 3 | 4:4 | 0 | |
| 9 | 1. FC Neubrandenburg 04 | 2 | 3 | 3:3 | 0 | |
| 10 | SC Borea Dresden | 2 | 3 | 2:2 | 0 | |
| 11 | 1. FC Lokomotive Leipzig | 2 | 3 | 4:5 | -1 | |
| 12 | Tennis Borussia Berlin | 2 | 2 | 4:4 | 0 | |
| 13 | SSV 07 Schlotheim | 1 | 1 | 1:1 | 0 | |
| 14 | Füchse Berlin | 1 | 1 | 0:0 | 0 | |
| 15 | FC Mecklenburg Schwerin | 2 | 1 | 1:4 | -3 | |
| 16 | SV Dessau 05 | 2 | 1 | 1:6 | -5 | |
| 17 | SG Dynamo Dresden II | 2 | 1 | 1:9 | -8 | |
| 18 | SV Empor Berlin | 2 | 0 | 2:5 | -3 | |
| 19 | FC Carl Zeiss Jena II | 2 | 0 | 2:6 | -4 |
Hinweis: Tabellenstand ohne vorgezogene Spiele!
| 11.09.2021 11:00 | FC Mecklenburg Schwerin | - | SG Dynamo Dresden II | 3 | : | 1 |
| 11.09.2021 12:00 | FC Rot-Weiß Erfurt | - | FSV Bernau | 2 | : | 1 |
| 11.09.2021 12:00 | SV Dessau 05 | - | Hertha BSC II | 0 | : | 2 |
| 11.09.2021 13:00 | SSV 07 Schlotheim | - | RasenBallsport Leipzig II | 0 | : | 2 |
| 12.09.2021 11:00 | 1. FC Lokomotive Leipzig | - | 1. FC Neubrandenburg 04 | 5 | : | 0 |
| 12.09.2021 12:00 | 1. FC Union Berlin II | - | SV Empor Berlin | 1 | : | 1 |
| 12.09.2021 12:00 | SC Borea Dresden | - | SV Babelsberg 03 | 3 | : | 0 |
| 12.09.2021 12:00 | FC Carl Zeiss Jena II | - | Hallescher FC II | 2 | : | 1 |
| 12.09.2021 12:00 | Tennis Borussia Berlin | - | Füchse Berlin | 0 | : | 1 |
Spielfrei: 1. FC Magdeburg