| 27.08.2021 14:30 | FC Carl Zeiss Jena II | - | RasenBallsport Leipzig II | 1 | : | 4 |
| 28.08.2021 11:00 | 1. FC Lokomotive Leipzig | - | Hallescher FC II | 1 | : | 4 |
| 28.08.2021 12:00 | SC Borea Dresden | - | SV Empor Berlin | 2 | : | 1 |
| 28.08.2021 13:00 | FC Mecklenburg Schwerin | - | SV Babelsberg 03 | 1 | : | 1 |
| 29.08.2021 10:30 | FC Rot-Weiß Erfurt | - | 1. FC Neubrandenburg 04 | 3 | : | 2 |
| 29.08.2021 12:00 | 1. FC Union Berlin II | - | Hertha BSC II | 2 | : | 2 |
| 29.08.2021 12:00 | 1. FC Magdeburg | - | SG Dynamo Dresden II | 8 | : | 0 |
| 29.08.2021 12:00 | Tennis Borussia Berlin | - | FSV Bernau | 3 | : | 3 |
| 29.08.2021 14:00 | SV Dessau 05 | - | SSV 07 Schlotheim | 1 | : | 1 |
Spielfrei: Füchse Berlin
| Sp. | Pkt. | Tore | Diff. | |||
|---|---|---|---|---|---|---|
| 1 | 1. FC Magdeburg | 1 | 3 | 8:0 | 8 | |
| 2 | RasenBallsport Leipzig II | 1 | 3 | 4:1 | 3 | |
| 3 | Hallescher FC II | 1 | 3 | 4:1 | 3 | |
| 4 | FC Rot-Weiß Erfurt | 1 | 3 | 3:2 | 1 | |
| 5 | SC Borea Dresden | 1 | 3 | 2:1 | 1 | |
| 6 | Tennis Borussia Berlin | 1 | 1 | 3:3 | 0 | |
| 7 | FSV Bernau | 1 | 1 | 3:3 | 0 | |
| 8 | Hertha BSC II | 1 | 1 | 2:2 | 0 | |
| 9 | 1. FC Union Berlin II | 1 | 1 | 2:2 | 0 | |
| 10 | SV Dessau 05 | 1 | 1 | 1:1 | 0 | |
| 11 | FC Mecklenburg Schwerin | 1 | 1 | 1:1 | 0 | |
| 12 | SV Babelsberg 03 | 1 | 1 | 1:1 | 0 | |
| 13 | SSV 07 Schlotheim | 1 | 1 | 1:1 | 0 | |
| 14 | Füchse Berlin | 0 | 0 | 0:0 | 0 | |
| 15 | 1. FC Neubrandenburg 04 | 1 | 0 | 2:3 | -1 | |
| 16 | SV Empor Berlin | 1 | 0 | 1:2 | -1 | |
| 17 | 1. FC Lokomotive Leipzig | 1 | 0 | 1:4 | -3 | |
| 18 | FC Carl Zeiss Jena II | 1 | 0 | 1:4 | -3 | |
| 19 | SG Dynamo Dresden II | 1 | 0 | 0:8 | -8 |
Hinweis: Tabellenstand ohne vorgezogene Spiele!
| 03.09.2021 18:30 | RasenBallsport Leipzig II | - | SV Dessau 05 | 5 | : | 0 |
| 04.09.2021 12:00 | SV Empor Berlin | - | 1. FC Lokomotive Leipzig | 1 | : | 3 |
| 04.09.2021 13:00 | Hertha BSC II | - | FC Carl Zeiss Jena II | 2 | : | 1 |
| 05.09.2021 11:00 | 1. FC Neubrandenburg 04 | - | SC Borea Dresden | 1 | : | 0 |
| 05.09.2021 12:00 | SG Dynamo Dresden II | - | Tennis Borussia Berlin | 1 | : | 1 |
| 05.09.2021 12:00 | FSV Bernau | - | FC Mecklenburg Schwerin | 3 | : | 0 |
| 05.09.2021 12:00 | SV Babelsberg 03 | - | FC Rot-Weiß Erfurt | 2 | : | 1 |
| 20.11.2021 13:00 | Füchse Berlin | - | 1. FC Magdeburg | 0 | : | 0 |
| 27.02.2022 13:00 | Hallescher FC II | - | 1. FC Union Berlin II | 0 | : | 3 |
Spielfrei: SSV 07 Schlotheim