| 23.04.2022 13:00 | F.C. Hansa Rostock | - | RasenBallsport Leipzig | 1 | : | 3 |
| 23.04.2022 13:00 | Hamburger SV | - | VfL Osnabrück | 4 | : | 1 |
| 23.04.2022 13:00 | Hannover 96 | - | Chemnitzer FC | 1 | : | 0 |
| 23.04.2022 13:00 | FC Energie Cottbus | - | KSV Holstein Kiel | 2 | : | 1 |
| 23.04.2022 13:00 | Hertha BSC | - | FC Viktoria 1889 Berlin | 1 | : | 0 |
| 23.04.2022 13:00 | FC St. Pauli | - | FC Carl Zeiss Jena | 2 | : | 0 |
| 23.04.2022 13:00 | SV Werder Bremen | - | Hallescher FC | 2 | : | 3 |
| 23.04.2022 13:00 | 1. FC Magdeburg | - | SG Dynamo Dresden | 2 | : | 2 |
| 23.04.2022 13:00 | 1. FC Union Berlin | - | Eimsbütteler TV | 0 | : | 3 |
Spielfrei: VfL Wolfsburg
| Sp. | Pkt. | Tore | Diff. | |||
|---|---|---|---|---|---|---|
| 1 | Hertha BSC | 18 | 44 | 46:22 | 24 | |
| 2 | FC Energie Cottbus | 18 | 39 | 32:19 | 13 | |
| 3 | RasenBallsport Leipzig | 18 | 37 | 44:20 | 24 | |
| 4 | SV Werder Bremen | 18 | 32 | 43:37 | 6 | |
| 5 | KSV Holstein Kiel | 18 | 32 | 28:25 | 3 | |
| 6 | FC Viktoria 1889 Berlin | 18 | 30 | 31:20 | 11 | |
| 7 | VfL Wolfsburg | 18 | 27 | 22:21 | 1 | |
| 8 | 1. FC Union Berlin | 18 | 26 | 26:27 | -1 | |
| 9 | Hannover 96 | 18 | 25 | 25:22 | 3 | |
| 10 | Hamburger SV | 18 | 25 | 35:33 | 2 | |
| 11 | F.C. Hansa Rostock | 18 | 24 | 32:24 | 8 | |
| 12 | SG Dynamo Dresden | 18 | 22 | 26:23 | 3 | |
| 13 | 1. FC Magdeburg | 18 | 21 | 33:31 | 2 | |
| 14 | FC St. Pauli | 18 | 21 | 34:36 | -2 | |
| 15 | Hallescher FC | 18 | 21 | 19:34 | -15 | |
| 16 | VfL Osnabrück | 18 | 19 | 21:41 | -20 | |
| 17 | Chemnitzer FC | 18 | 16 | 16:30 | -14 | |
| 18 | Eimsbütteler TV | 18 | 13 | 18:37 | -19 | |
| 19 | FC Carl Zeiss Jena | 18 | 5 | 12:41 | -29 |
Hinweis: Tabellenstand ohne vorgezogene Spiele!
Spielfrei: VfL Wolfsburg