| 21.08.2021 11:00 | Chemnitzer FC | - | Hamburger SV | 1 | : | 1 |
| 21.08.2021 11:00 | Eimsbütteler TV | - | FC Energie Cottbus | 1 | : | 2 |
| 21.08.2021 11:00 | RasenBallsport Leipzig | - | FC St. Pauli | 2 | : | 2 |
| 21.08.2021 11:00 | KSV Holstein Kiel | - | FC Carl Zeiss Jena | 2 | : | 1 |
| 21.08.2021 12:00 | VfL Wolfsburg | - | 1. FC Magdeburg | 2 | : | 1 |
| 21.08.2021 13:00 | Hallescher FC | - | 1. FC Union Berlin | 1 | : | 3 |
| 22.08.2021 11:00 | SG Dynamo Dresden | - | F.C. Hansa Rostock | 2 | : | 1 |
| 22.08.2021 11:00 | SV Werder Bremen | - | Hertha BSC | 2 | : | 5 |
| 22.08.2021 13:00 | FC Viktoria 1889 Berlin | - | Hannover 96 | 1 | : | 1 |
Spielfrei: VfL Osnabrück
| Sp. | Pkt. | Tore | Diff. | |||
|---|---|---|---|---|---|---|
| 1 | KSV Holstein Kiel | 2 | 6 | 8:4 | 4 | |
| 2 | Hertha BSC | 2 | 6 | 7:3 | 4 | |
| 3 | FC Energie Cottbus | 2 | 6 | 4:1 | 3 | |
| 4 | RasenBallsport Leipzig | 2 | 4 | 5:2 | 3 | |
| 5 | 1. FC Union Berlin | 2 | 4 | 3:1 | 2 | |
| 6 | Hannover 96 | 2 | 4 | 2:1 | 1 | |
| 7 | VfL Wolfsburg | 2 | 3 | 3:3 | 0 | |
| 8 | Eimsbütteler TV | 2 | 3 | 2:2 | 0 | |
| 9 | SG Dynamo Dresden | 2 | 3 | 2:2 | 0 | |
| 10 | Hallescher FC | 2 | 3 | 3:4 | -1 | |
| 11 | FC Viktoria 1889 Berlin | 2 | 2 | 1:1 | 0 | |
| 12 | VfL Osnabrück | 1 | 1 | 0:0 | 0 | |
| 13 | FC Carl Zeiss Jena | 2 | 1 | 1:2 | -1 | |
| 14 | Chemnitzer FC | 2 | 1 | 1:3 | -2 | |
| 15 | FC St. Pauli | 2 | 1 | 5:8 | -3 | |
| 16 | Hamburger SV | 2 | 1 | 1:4 | -3 | |
| 17 | 1. FC Magdeburg | 2 | 0 | 2:4 | -2 | |
| 18 | F.C. Hansa Rostock | 2 | 0 | 1:3 | -2 | |
| 19 | SV Werder Bremen | 1 | 0 | 2:5 | -3 |
Hinweis: Tabellenstand ohne vorgezogene Spiele!
| 11.09.2021 11:00 | Hamburger SV | - | Eimsbütteler TV | 2 | : | 0 |
| 11.09.2021 11:00 | FC St. Pauli | - | Chemnitzer FC | 3 | : | 0 |
| 11.09.2021 12:00 | F.C. Hansa Rostock | - | FC Viktoria 1889 Berlin | 4 | : | 2 |
| 11.09.2021 12:00 | FC Carl Zeiss Jena | - | RasenBallsport Leipzig | 0 | : | 1 |
| 11.09.2021 12:30 | FC Energie Cottbus | - | SG Dynamo Dresden | 1 | : | 0 |
| 11.09.2021 13:00 | 1. FC Union Berlin | - | VfL Wolfsburg | 2 | : | 2 |
| 12.09.2021 11:00 | VfL Osnabrück | - | KSV Holstein Kiel | 0 | : | 2 |
| 27.10.2021 14:00 | Hannover 96 | - | Hallescher FC | 2 | : | 0 |
| 06.11.2021 14:00 | 1. FC Magdeburg | - | SV Werder Bremen | 1 | : | 3 |
Spielfrei: Hertha BSC